Correction of cortisol overreplacement ameliorates morbidities in patients with hypopituitarism: a pilot study

Escrito por Dr. Oscar Domingo Bruno Imprimir

Nuestro agradecimiento al Dr. Oscar. D. Bruno por compartir este valioso material.

Abstract: Context Hyporituitarism in adults is known to be associated with deleterious effects on body composition, lipid profile and quality of life (QoL). This was attributed to GH deficiency. The potential role of glucocorticoid overreplacement had never been investigated. Objective To investigate whether reduction in glucocorticoid replace- ment dose to more physiological one could ameliorate the ‘‘AO-GHD’’-attributed symptomatology in patients with hypopituitarism. Design Eleven patients with panhypopi- tuitarism taking 20–30 mg/day of hydrocortisone, but on no GH replacement were switched to 10–15 mg of hydrocortisone daily. Both basally and 6–12 months later, their body mass index, body composition by dual-energy X-ray absorptiometry, lipid profile, and the score of quality of life, QOL-AGHDA were measured. Results Within 6– 12 months of lower hydrocortisone dose, subjects lost an average of 7.1 kg of total body fat and 4.1 kg of abdominal fat. No changes were seen in lean body mass, bone mineral content and HOMA-IR. Plasma total cholesterol and tri- glyceride concentrations decreased significantly (\0.05) and the QoL improved (P = 0.018). Conclusions Our pilot study suggests that decreasing the glucocorticoid replacement dose to *15 mg/day is beneficial in terms of patients’ body composition, lipid profile and quality of life.


Cortisol overreplacement


ƚltima actualizaciĆ³n el 29 de Octubre de 2019